Practice Points:  Assessment of therapies across a range of animal models, with careful safety and pharmacokinetic studies, is vital before clinical translation. Clinical neuroprotection trials

Practice Points:  Cool to a central body temperature of 33.5 ◦C for 72 h as soon as possible in term and near-term neonates with moderate

Practice Points:  Therapeutic hypothermia has become a standard care for treating qualifying neonates with neonatal encephalopathy. Criteria for cooling generally include evidence of an intrapartum

Practice Points:  A shared decision making approach should be used in decision making for encephalopathic neonates treated with therapeutic hypothermia. Clinicians and parents must balance

Practice Points:  Neonatal encephalopathy (NE) is a clinical diagnosis which may arise from numerous etiologies HIE may be distinguished from NE due to other causes

Practice Points:  Therapeutic Hypothermia is a safe and effective treatment which reduces the impact of neural injury following hypoxia ischaemia and moderate/severe neonatal encephalopathy. Despite