SFNM NE Series: Subcutaneous fat necrosis associated with hypercalcemia in neonates with neonatal encephalopathy treated with therapeutic hypothermia

Practice Points: 

• Clinicians looking after neonates with NE treated with TH must be aware of SFNN and must be assessed the neonates routinely for SFNN

• Routine clinical and biochemical monitoring for hypercalcemia in those with SFNN or at-risk is critical

• Hypercalcemia is typically detected at a month of age; half the neonates are asymptomatic

• Prompt intervention often including hospitalization reduces morbidity and mortality

• Treatment may include low calcium-vitamin D formula or bisphosphonates with supervision by pediatric endocrinology

PubMed Link

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