SFNM NE Series: Management of comfort and sedation in neonates with neonatal encephalopathy treated with therapeutic hypothermia

Practice Points: 

• Non-pharmacologic approaches form the foundation for providing comfort for neonates with NE receiving TH

• Benzodiazepines should be avoided for sedation

• Morphine 50 μg/kg followed by a continuous infusion of 5 μg/kg/hour currently represents the approach to pharmacologic sedation with the strongest basis in evidence

• Low-dose dexmedetomidine infusion may be considered as an alternative to morphine infusion in the setting of appropriate monitoring for bradycardia

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