Newborn Brain Society

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Call For Nominations!

The Newborn Brain Society is pleased to announce a Call for Nominations for or members interested in serving as Chair/Director and as Committee Member for our various Committees. Nomination are being accepted for the following positions. One (1) – Chair of Membership Committee & Board Member One (1) – Education Committee Member One (1) – …

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SFNM NE Series: Proposing a care practice bundle for neonatal encephalopathy during therapeutic hypothermia

Practice Points:  Neonates with NE often present with multi-organ dysfunction that requires multidisciplinary specialized management. Care of the neonates with NE is thus complex with interaction between the brain and the various organ systems. Illness severity during the first days of life, and not only during the initial asphyxia event, is a significant predictor of …

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SFNM NE Series: Need for more evidence in the prevention and management of perinatal asphyxia and neonatal encephalopathy in low and middle-income countries: A call for action

Practice Points:  Therapeutic hypothermia alongside optimal supportive care increases mortality and does not provide neuroprotection after NE in tertiary neonatal intensive care units in south Asia. Meticulous attention to supportive care, including avoidance of hyperthermia, hyperoxia, hypocarbia, hypoglycemia, and appropriate seizure management, remain the most important steps to reduce brain injury. PubMed Link To view …

SFNM NE Series: Need for more evidence in the prevention and management of perinatal asphyxia and neonatal encephalopathy in low and middle-income countries: A call for action Read More »

SFNM NE Series: Therapies for neonatal encephalopathy: Targeting the latent, secondary and tertiary phases of evolving brain injury

Practice Points:  Assessment of therapies across a range of animal models, with careful safety and pharmacokinetic studies, is vital before clinical translation. Clinical neuroprotection trials in neonates with NE need careful planning, with adequate power and pharmacokinetic information built into the protocols. Determination of optimal dose and timing of each agent will be important as …

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SFNM NE Series: Unanswered questions regarding therapeutic hypothermia for neonates with neonatal encephalopathy

Practice Points:  Cool to a central body temperature of 33.5 ◦C for 72 h as soon as possible in term and near-term neonates with moderate and severe NE. TH for term and near-term newborns with mild NE remains debated with insufficient systematic evidence proving improved neuro- developmental outcome with treatment, and without a clear picture …

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SFNM NE Series: Medico-legal considerations in the context of neonatal encephalopathy and therapeutic hypothermia

Practice Points:  Therapeutic hypothermia has become a standard care for treating qualifying neonates with neonatal encephalopathy. Criteria for cooling generally include evidence of an intrapartum sentinel event, significant metabolic acidosis on an umbilical cord or immediate neonatal blood gas specimen, and evidence of neonatal encephalopathy. They should meet the criteria from published clinical trials. Clinicians …

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SFNM NE Series: Ethical considerations in the care of encephalopathic neonates treated with therapeutic hypothermia

Practice Points:  A shared decision making approach should be used in decision making for encephalopathic neonates treated with therapeutic hypothermia. Clinicians and parents must balance complementary ethical justifications, including the best interest standard, harm principle, and relational potential standard. The estimation and communication of prognosis is complex and requires preparation, reflection, and humility. Clinicians must …

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SFNM NE Series: Neurological and developmental outcomes following neonatal encephalopathy treated with therapeutic hypothermia

Practice Points:  Therapeutic Hypothermia is a safe and effective treatment which reduces the impact of neural injury following hypoxia ischaemia and moderate/severe neonatal encephalopathy. Despite TH, a high proportion of survivors still develop moderate/ severe disability necessitating close follow up into childhood designed to identify neuromotor, cognitive and behavioural prob- lems. Early referral to child …

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