Newborn Brain Society

SFNM NE Series: Hemodynamic optimization for neonates with neonatal encephalopathy caused by a hypoxic ischemic event: Physiological and therapeutic considerations

Practice Points: 

  • Neonatal encephalopathy due to a hypoxic ischemic event is commonly associated with cardiac dysfunction and acute pulmonary hypertension
  • Therapeutic hypothermia and rewarming modify loading conditions and blood flow and careful adjustment of inotropic agents is recommended.
  • Delineating the physiology during therapeutic hypothermia clinically is difficult
  • Comprehensive, quantitative echocardiography can assist with delineating pulmonary vascular and cardiac contributions to illness state
  • Commonly used cardiovascular agents can have unintended consequences and should be used cautiously taking physiologic principles into account

PubMed Link

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