Newborn Brain Society

SFNM NE Series: Challenges in respiratory management during therapeutic hypothermia for neonatal encephalopathy

Practice Points: 

  • During TH:
  • Achieve peripheral oxygen saturation with the least possible fraction of inspired oxygen (FiO2)
  • Minimize ventilation settings if intubated to avoid hypocapnia
  • Heat inspired gas to 37 ◦C and ensure 100% relative humidity
  • Interpret blood gas values corrected for the actual temperature of the infant
  • May use mild sedation to overcome any discomfort related to cooling
  • Avoid:
  • Hyperventilation and hyperoxemia, as hypocapnia and oxygen radicals can contribute to brain damage
  • The use of alkaline buffers, paralytic agents and heavy sedation, since these medications have serious side effects on the brain

PubMed Link

To view the full text and an associated presentation, become a NBS member here

Leave a Comment